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Groupe de Ena esineve

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To access your Medicare Dental Benefits, members can view the Humana Medicare Advantage Benefit Descriptions to locate the benefits listed under their DEN number. Each dental plan can be identified by its unique 3-digit dental (DENxxx), which is found on the back of your Humana Medicare Advantage member ID card.


A total of 69,398 transcriptome assembled contigs (TACs), amounting to 43 Mb in total, were identified using pearl millet transcriptome sequences from two different studies16,17 and a new pearl millet transcriptome assembly generated for this study (Supplementary Table 8). Ab initio homology-based gene prediction were combined with transcript assembly to infer a non-redundant set of 38,579 gene models with an average transcript size of 2,420 bp and an average coding sequence of 1,014 bp (Table 1; Supplementary Table 9). The average lengths of mRNA, CDS, introns and exons in pearl millet were similar to those reported for other cereal genomes (Supplementary Fig. 8). Among 458 of the most conserved genes in CEGMA, 437 (95.4%) genes were complete but 8 (1.7%) genes were not found in the genome sequence, 8 (1.7%) genes were not included in the gene set, and 5 (1.1%) genes had more than one copy (possibly fragmented genes). In addition, for 956 genes in benchmarking universal single-copy orthologs (BUSCO) analysis, we annotated 96.7% genes, and 95.4% of these are complete. Gene models of rice and Arabidopsis thaliana have been annotated and carefully validated. We chose to use the gene models of rice, which is more closely related to pearl millet than A. thaliana, to investigate the completeness of pearl millet genes. Of the 4,202 single-copy genes in rice, 90.86% have homologs in pearl millet, and 86% of these pearl millet genes were complete when compared with rice gene models (ratio of pearl millet length/rice length 0.8), reflecting the completeness of single-copy genes. Gene density increased toward the ends of pseudomolecules (Fig. 1), consistent with findings in all other cereal genomes published to date11,14,15. Most of the annotated genes coded for proteins with homology to proteins in SwissProt18 (55.61%) and InterPro (ref. 19) (65.53%). Functions were assigned to 27,893 (72.30%) genes, leaving 10,686 (27.70%) genes unannotated (Supplementary Table 10).


Expansion and contraction of gene families between species might also highlight differences in bioinformatics analysis carried out for different genomes. Bias in gene model identification among different studies might render a comparison of expansion or contraction challenging. One potential source of bias is if a gene is split, that is, a complete gene is instead annotated as two separate genes. Based on eukaryotic orthologous gene sequences, we estimate that 2.3% of our genes might have been misannotated in this way (Supplementary Table 6). Although we found that 1,692 families were contracted in pearl millet, contraction is 5.4 times more likely than expansion. One explanation may be that there was a far higher proportion of split genes in the reference genomes of the other species that we use for comparison than in our pearl millet assembly. This would make our number of gene family contractions an overestimate.


Domestication in pearl millet, like that observed in maize24, was associated with profound modifications of spike morphology and plant architecture (Fig. 3c). We found several genomic regions that showed reduced diversity in the cultivated (but not wild) species that may harbor genes selected for during domestication. Using a negative log ratio of diversity between cultivated (red) and wild (blue) samples, values close to 1 indicate a tenfold decrease in diversity whereas values close to 0 indicate that diversity is maintained in the cultivated samples. We also identified regions with an excess of differentiation based on a fixation index (FST) measure (Supplementary Fig. 18). These analyses provided orthogonal and consistent results and identified 140 genomic regions with values above the 95% threshold for both loss of diversity and differentiation. Using a stringent threshold of 99.5%, and considering only values identified by both statistics, 24 genomic regions had reduced diversity in the cultivated germplasm, of which eight were located on Pg7, six on Pg6 and five on Pg1 (Supplementary Tables 34 and 35). Linkage groups 6 and 7 have previously been identified as carrying QTL that explain most phenotypic differences between wild and cultivated pearl millet germplasm41,42. Most of the identified regions have negative Tajima's D values (


We applied our resequencing data to carry out genomic selection to predict grain yield for test crosses. Four scenarios of prediction were investigated, namely the performance of grain yield in each of the three environments (control, early stress and late stress) and across environments. We observe high prediction accuracy, measured as the Pearson correlation coefficient between the predicted and observed values, standardized with the square root of the heritability (h = 0.78), amounting to 0.6 for the performance across environments. Analyses of this kind have been undertaken for grain yield in other crops using genomic selection46. A modelling study recently found that with this level of prediction accuracy, genomic selection could substantially improve selection gain per year47.


A Residential Assisted Living Facility is a facility or residence operated on either a profit or nonprofit basis for the purpose of providing necessary supervision, personal assistance, meals, and lodging to three or more adults not related to the owner. On this page, find information needed to become licensed and maintain compliance with the rules, access training resources, announcements, and tools.


In 2016, West Des Moines Community Schools recognized the need for a central location to support student learning. The following year, Canvas became our official learning management system (LMS). This was an exciting action for our district, providing many opportunities to support 21st century skills. A learning management system is a software that helps provide, track, and report on classes and assignments. Canvas provides parents and students with greater access to their curriculum and learning by housing important student curricular expectations and information. This could include their online textbook, links to resources, homework, videos, assessments, online discussions, and so much more.


Log Name: ApplicationSource: MSDPMDate: Event ID: 976Task Category: NoneLevel: ErrorKeywords: ClassicUser: N/AComputer: Description:The description for Event ID 976 from source MSDPM cannot be found. Either the component that raises this event is not installed on your local computer or the installation is corrupted. You can install or repair the component on the local computer.The DPM job failed because it could not contact the DPM engine.


The criminal enforcement agreement defers prosecution for criminal violations of the Lacey Act and requires Gibson to pay a penalty amount of $300,000. The agreement further provides for a community service payment of $50,000 to the National Fish and Wildlife Foundation to be used to promote the conservation, identification and propagation of protected tree species used in the musical instrument industry and the forests where those species are found. Gibson will also implement a compliance program designed to strengthen its compliance controls and procedures. In related civil forfeiture actions, Gibson will withdraw its claims to the wood seized in the course of the criminal investigation, including Madagascar ebony from shipments with a total invoice value of $261,844.


Indian Affairs supports and assists the tribes as they develop their governmental structures and operations, build strong and safe communities, and provide services to their members. Indian Affairs-funded programs include education, economic and workforce development, social services, justice (law enforcement, corrections, and courts), infrastructure (road, bridges, and dams), housing, realty, agriculture and range management, and natural resources management and protection. Besides Indian Affairs, there are other Federal agencies with programs developed specifically to serve AI/ANs and their tribal communities. 041b061a72


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